Molecular Diagnostics Moves Into Prostate Cancer

Article preview from Medtech Insight - July 2013

While the PSA test is still widely recognized as a valuable prostate cancer screening tool, its dismal accuracy record has created an acute need for more effective and informative alternatives, and the field of molecular diagnostics, based on gene-based biomarkers, is leading the charge.

Molecular Diagnostics Moves Into Prostate Cancer

Article preview from Medtech Insight - July 2013

The numbers are almost as startling as the controversy. One in six men will develop prostate cancer in their lifetime, with nearly 240,000 American men expected to be diagnosed this year, according to the American Cancer Society. And more than 29,000 US men will die of the disease, more than any other form of cancer besides lung cancer. Yet, even with the large number of annual deaths from prostate cancer, the health care community continues to deal with assertions, debates, and scientific-based evidence that the disease is being overtreated. The conundrum has become a hallmark of the prostate cancer market, where the introduction in the late 1980s of the prostate-specific antigen (PSA) test was heralded as a turning point in cancer detection. However, while the PSA test is still widely viwed as a valuable screening tool, its dismal accuracy record – especially considering how much the PSA test is utilized – has created a huge opportunity for more effective, gene-based biomarkers, several of which are ready or close to market now.

The list of new and upcoming prostate cancer biomarkers was a chief topic among urologists who gathered at the recent American Urological Association (AUA) Annual Meeting in San Diego to learn firsthand about the latest technology being developed that could improve the management of prostate cancer. Ironically, as manufacturers and scientists at the meeting offered data and demonstrations on biomarkers that could help address the overtreatment issue, the controversy was inflamed somewhat by news announced a couple of months earlier. In April, the AUA issued new guidelines for the early detection of prostate cancer that recommended against PSA testing for several groups of men, including those under 40 years of age, those between 40 to 54 years old at average risk, those 70 years and older, and those with a life expectancy of less than 10 to 15 years.

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